The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain.

doi:10.1158/1078-0432.CCR-07-4436

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Article

The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2008

Milne Roger L, Osorio Ana, Cajal Teresa Ramón Y, Vega Ana, Llort Gemma, de la Hoya Miguel, Díez Orland, Alonso M Carmen, Lazaro Conxi, Blanco Ignacio, Sánchez-de-Abajo Ana, Caldés Trinidad, Blanco Ana, Graña Begoña, Durán Mercedes, Velasco Eladio, Chirivella Isabel, Cardeñosa Eva Esteban, Tejada María-Isabel, Beristain Elena, Miramar María-Dolores, Calvo María-Teresa, Martínez Eduardo, Guillén Carmen, Salazar Raquel, San Román Carlos, Antoniou Antonis C, Urioste Miguel, Benítez Javier

Abstract excerpt

PURPOSE: It is not clear that the published estimates of the breast and ovarian cancer penetrances of mutations in BRCA1 and BRCA2 can be used in genetic counseling in countries such as Spain, where the incidence of breast cancer in the general population is considerably lower, the prevalence of BRCA2 mutations seems to be higher, and a distinct spectrum of recurrent mutations exists for both genes. We aimed to...

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Identifiers

PMID: 18451254
DOI: 10.1158/1078-0432.CCR-07-4436

Genes

BRCA1
BRCA2

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Source receipt: pubmed, retrieved 6 Sept 2026.

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