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Article

Modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: systematic review and meta-analysis.

Journal of the National Cancer Institute - 1 Jun 2014

Friebel Tara M, Domchek Susan M, Rebbeck Timothy R

Abstract excerpt

BACKGROUND: There is substantial variability in cancer risk in women who have inherited a BRCA1 or BRCA2 (BRCA1/2) mutation. Numerous factors have been hypothesized to modify these risks, but studies are of variable quality, and it remains unclear which of these may be of value in clinical risk assessment. METHODS: PubMed and Web of Science databases were searched for articles published through September 2013....

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Source

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Identifiers

PMID: 24824314
DOI: 10.1093/jnci/dju091
PMCID: PMC4081625

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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