Article
Breast cancer risk for noncarriers of family-specific BRCA1 and BRCA2 mutations: findings from the Breast Cancer Family Registry.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Dec 2011
Kurian Allison W, Gong Gail D, John Esther M, Johnston David A, Felberg Anna, West Dee W, Miron Alexander, Andrulis Irene L, Hopper John L, Knight Julia A, Ozcelik Hilmi, Dite Gillian S, Apicella Carmel, Southey Melissa C, Whittemore Alice S
Abstract excerpt
PURPOSE: Women with germline BRCA1 and BRCA2 mutations have five- to 20-fold increased risks of developing breast and ovarian cancer. A recent study claimed that women testing negative for their family-specific BRCA1 or BRCA2 mutation (noncarriers) have a five-fold increased risk of breast cancer. We estimated breast cancer risks for noncarriers by using a population-based sample of patients with breast cancer...
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