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Article

Survival analysis of cancer risk reduction strategies for BRCA1/2 mutation carriers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jan 2010

Kurian Allison W, Sigal Bronislava M, Plevritis Sylvia K

Abstract excerpt

PURPOSE: Women with BRCA1/2 mutations inherit high risks of breast and ovarian cancer; options to reduce cancer mortality include prophylactic surgery or breast screening, but their efficacy has never been empirically compared. We used decision analysis to simulate risk-reducing strategies in BRCA1/2 mutation carriers and to compare resulting survival probability and causes of death. METHODS: We developed a Monte...

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Source

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Identifiers

PMID: 19996031
DOI: 10.1200/JCO.2009.22.7991
PMCID: PMC2815712

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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