Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population.

PloS one - 1 Jan 2015

Dong Zheng, Zhao Dongbao, Yang Chengde, Zhou Jingru, Qian Qiaoxia, Ma Yanyun, He Hongjun, Ji Hengdong, Yang Yajun, Wang Xiaofeng, Xu Xia, Pang Yafei, Zou Hejian, Jin Li, Wang Jiucun

Abstract excerpt

Gout is a common inflammation disease resulting from an increase in serum uric acid. Nearly 70% of uric acid is excreted via the kidneys. To date, evidence for an association between genetic loci and gout is absent, equivocal or not replicated. Our study aims to test variants in two genes abundantly expressed in the kidney, LRP2 and COMT, for their association with uric acid and gout. In total, 1318 Chinese...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Gene Frequency

Share to Low Density Lipoprotein Receptor-Related Protein-2

Share to Uric Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 26147675
DOI: 10.1371/journal.pone.0131302
PMCID: PMC4493088

Genes

LRP2
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population.PMID 26147675Read ↗

A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population.Semantic proximity Read ↗

Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility.Semantic proximity Read ↗

Polymorphisms of uric transporter proteins in the pathogenesis of gout in a Chinese Han population.Semantic proximity Read ↗

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.Semantic proximity Read ↗

Common UCP2 variants contribute to serum urate concentrations and the risk of hyperuricemia.Semantic proximity Read ↗

Genetic Association Between SLC22A12 Variants and Susceptibility to Hyperuricemia: A Meta-Analysis.Semantic proximity Read ↗

Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to GoutSemantic proximity Read ↗

Common variants related to serum uric acid concentrations are associated with glucose metabolism and insulin secretion in a Chinese population.Semantic proximity Read ↗

Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case-control study.Semantic proximity Read ↗

Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levelsSemantic proximity Read ↗

Genetic variation in WDR1 is associated with gout risk and gout-related metabolic indices in the Han Chinese population.Semantic proximity Read ↗

Novel Genetic Variants Associated with Gout Identified Through a Genome-Wide Study in the UK Biobank (N = 150,542)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.