Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common UCP2 variants contribute to serum urate concentrations and the risk of hyperuricemia.

Scientific reports - 8 Jun 2016

Yang Luyu, Dong Zheng, Zhou Jingru, Ma Yanyun, Pu Weilin, Zhao Dongbao, He Hongjun, Ji Hengdong, Yang Yajun, Wang Xiaofeng, Xu Xia, Pang Yafei, Zou Hejian, Jin Li, Yang Chengde, Wang Jiucun

Abstract excerpt

Elevated serum urate, which is regulated at multiple levels including genetic variants, is a risk factor for gout and other metabolic diseases. This study aimed to investigate the association between UCP2 variants and serum urate as well as hyperuricemia in a Chinese population. In total, 4332 individuals were genotyped for two common UCP2 variants, -866G/A and Ala55Val. These loci were not associated either...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Asian People

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hyperuricemia

Share to Overweight

Share to Point Mutation

Share to Sex Characteristics

Share to Uncoupling Protein 2

Share to Uric Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 27273589
DOI: 10.1038/srep27279
PMCID: PMC4897637

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common UCP2 variants contribute to serum urate concentrations and the risk of hyperuricemia.PMID 27273589Read ↗

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk FactorsSemantic proximity Read ↗

The Epidemiology and Genetics of Hyperuricemia and Gout across Major Racial Groups: A Literature Review and Population Genetics Secondary Database AnalysisSemantic proximity Read ↗

The Epidemiology and Genetics of Hyperuricemia and Gout Across Major Racial Groups: A literature Review and Population Genetics Secondary Data AnalysisSemantic proximity Read ↗

Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1.Semantic proximity Read ↗

An update of genetics, co‐morbidities and management of hyperuricaemiaSemantic proximity Read ↗

Association of ABCG2 rs2231142 Allele and BMI With Hyperuricemia in an East Asian PopulationSemantic proximity Read ↗

Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model miceSemantic proximity Read ↗

An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate.Semantic proximity Read ↗

Polymorphisms of uric transporter proteins in the pathogenesis of gout in a Chinese Han population.Semantic proximity Read ↗

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.Semantic proximity Read ↗

The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis.Semantic proximity Read ↗

Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.