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Article

In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress.

PLoS genetics - 1 Jul 2015

Anderson Blair R, Howell David N, Soldano Karen, Garrett Melanie E, Katsanis Nicholas, Telen Marilyn J, Davis Erica E, Ashley-Koch Allison E

Abstract excerpt

African Americans have a disproportionate risk for developing nephropathy. This disparity has been attributed to coding variants (G1 and G2) in apolipoprotein L1 (APOL1); however, there is little functional evidence supporting the role of this protein in renal function. Here, we combined genetics and in vivo modeling to examine the role of apol1 in glomerular development and pronephric filtration and to test the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26147622
DOI: 10.1371/journal.pgen.1005349
PMCID: PMC4492502

Genes

APOL1
MYH9
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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