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Article

Epistatic interaction between common AGT G(-6)A (rs5051) and AGTR1 A1166C (rs5186) variants contributes to variation in kidney size at birth.

Gene - 1 Nov 2015

Kaczmarczyk Mariusz, Kuprjanowicz Anna, Łoniewska Beata, Gorący Iwona, Taryma-Leśniak Olga, Skonieczna-Żydecka Karolina, Ciechanowicz Andrzej

Abstract excerpt

Low nephron number has been recognised as an important cardiovascular risk factor and recently a strong correlation between renal mass and nephron number has been demonstrated in newborns. The aim of this study was to investigate individual, as well as combined, effects of common variants of genes which encode for major components of the renin-angiotensin system (REN G10601A, AGT G(-6)A, ACE I/D, AGTR1 A1166C) on...

Read the complete abstract on PubMed

Topics

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Share to Angiotensinogen
Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Kidney

Share to Nephrons

Share to Organ Size

Share to Quantitative Trait, Heritable

Share to Receptor, Angiotensin, Type 1

Source

Identifiers

PMID: 26142106
DOI: 10.1016/j.gene.2015.06.071

Genes

AGT
AGTR1
ACE
REN

Variants

rs5051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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