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Article

Combination of renin-angiotensin system polymorphisms is associated with altered renal sodium handling and hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 2004

Siani Alfonso, Russo Paola, Paolo Cappuccio Francesco, Iacone Roberto, Venezia Antonella, Russo Ornella, Barba Gianvincenzo, Iacoviello Licia, Strazzullo Pasquale

Abstract excerpt

Genes of the renin-angiotensin-aldosterone system (RAAS) are natural candidates for sodium homeostasis and blood pressure regulation. To investigate the effect of a combination of polymorphisms of RAAS genes on renal sodium handling and blood pressure, 918 participants to the Olivetti Heart Study were genotyped for the following polymorphisms: I/D of angiotensin converting enzyme (ACE), M235T of angiotensinogen...

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Source

Identifiers

PMID: 14967847
DOI: 10.1161/01.HYP.0000117985.57001.b3

Genes

ACE
AGT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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