Article
Interaction between gene polymorphisms of nitric oxide synthase and renin-angiotensin system in the progression of membranous glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2004
Stratta Piero, Bermond Francesca, Guarrera Simonetta, Canavese Caterina, Carturan Sonia, Dall'Omo Annamaria, Ciccone Giovannino, Bertola Laura, Mazzola Gina, Fasano Edvige, Matullo Giuseppe
Abstract excerpt
BACKGROUND: The renin-angiotensin system (RAS) and nitric oxide synthase (NOS) play a key role in the progression of primary glomerulonephritis (GN). Although previous studies have examined genetic risk associated with single gene variations, experiments assessing risk conferred by multiple gene variations are still scanty. METHODS: The effect of combination of variant alleles of four genes encoding for three...
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