Article
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo.
Cell - 2 Jul 2015
Soccio Raymond E, Chen Eric R, Rajapurkar Satyajit R, Safabakhsh Pegah, Marinis Jill M, Dispirito Joanna R, Emmett Matthew J, Briggs Erika R, Fang Bin, Everett Logan J, Lim Hee-Woong, Won Kyoung-Jae, Steger David J, Wu Ying, Civelek Mete, Voight Benjamin F, Lazar Mitchell A
Abstract excerpt
SNPs affecting disease risk often reside in non-coding genomic regions. Here, we show that SNPs are highly enriched at mouse strain-selective adipose tissue binding sites for PPARγ, a nuclear receptor for anti-diabetic drugs. Many such SNPs alter binding motifs for PPARγ or cooperating factors and functionally regulate nearby genes whose expression is strain selective and imbalanced in heterozygous F1 mice....
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