Article
Genetic susceptibility to malignant mesothelioma and exposure to asbestos: the influence of the familial factor.
Mutation research - 1 Jan 2000
Ugolini Donatella, Neri Monica, Ceppi Marcello, Cesario Alfredo, Dianzani Irma, Filiberti Rosangela, Gemignani Federica, Landi Stefano, Magnani Corrado, Mutti Luciano, Puntoni Riccardo, Bonassi Stefano
Abstract excerpt
BACKGROUND: Asbestos is the principal etiological factor of malignant mesothelioma (MM), accounting for more than 80% of all tumor cases. However, other co-factors, including genetic susceptibility may play a role in the etiology of this disease, possibly modulating the effects of exposure to asbestos and other carcinogenic mineral fibers. The frequent report of familial clustering was the first indication...
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