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Article

The role of GRIK4 gene in treatment-resistant depression.

Genetics research - 3 Jul 2015

Milanesi Elena, Bonvicini Cristian, Congiu Chiara, Bortolomasi Marco, Gainelli Giulio, Gennarelli Massimo, Minelli Alessandra

Abstract excerpt

Several lines of evidence implicate abnormalities in glutamatergic neural transmission in major depressive disorder (MDD) and treatment response. A high percentage of MDD patients do not respond adequately to antidepressants and are classified as having treatment-resistant depression (TRD). In this study we investigated five GRIK4 variants, previously associated with antidepressants response, in an Italian cohort...

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Source

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Identifiers

PMID: 26139080
DOI: 10.1017/S0016672315000142
PMCID: PMC6863631

Genes

TRD
GRIK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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