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Article

Pharmacogenetics studies in STAR*D: strengths, limitations, and results.

Psychiatric services (Washington, D.C.) - 1 Nov 2009

Laje Gonzalo, Perlis Roy H, Rush A John, McMahon Francis J

Abstract excerpt

Several lines of evidence support an important genetic contribution to the wide individual variation in therapeutic response to antidepressant medications. The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study provided the largest cohort assembled to date of DNA from patients with nonpsychotic major depressive disorder, uniformly treated with citalopram and followed prospectively for up to 12...

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Source

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Identifiers

PMID: 19880459
DOI: 10.1176/appi.ps.60.11.1446
PMCID: PMC3775610

Genes

GRIA3
GRIK2
BDNF
FKBP5
GRIA1
GRIK4
KCNK2
PAPLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Pharmacogenetics studies in STAR*D: strengths, limitations, and results.PMID 19880459Read ↗

Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort.Semantic proximity Read ↗

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Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.Semantic proximity Read ↗

Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D.Semantic proximity Read ↗

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Pharmacogenetics of major depressive disorder: top genes and pathways toward clinical applications.Semantic proximity Read ↗

Genome-wide association studies of antidepressant outcome: a brief review.Semantic proximity Read ↗

Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment.Semantic proximity Read ↗

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Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis.Semantic proximity Read ↗

Genetics of Treatment Outcomes in Major Depressive Disorder: Present and FutureSemantic proximity Read ↗

The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort.Semantic proximity Read ↗

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