Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression.

Neuropsychobiology - 1 Jan 2012

Serretti Alessandro, Chiesa Alberto, Crisafulli Concetta, Massat Isabelle, Linotte Sylvie, Calati Raffaella, Kasper Siegfried, Bailer Ursula, Lecrubier Yves, Fink Martin, Antonijevic Irina, Forray Carlos, Snyder Lenore, Bollen Joseph, Zohar Joseph, De Ronchi Diana, Souery Daniel, Mendlewicz Julien

Abstract excerpt

In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.

Read the complete abstract on PubMed

Topics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Depressive Disorder, Major
Share to Gene Frequency
Share to Genetic Association Studies
Share to Heterotrimeric GTP-Binding Proteins
Share to Receptors, Kainic Acid
Share to Regression Analysis
Share to Treatment Outcome

Source

Identifiers

PMID: 22222462
DOI: 10.1159/000329553

Genes

GNB3
GRIK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression.PMID 22222462Read ↗

The role of GRIK4 gene in treatment-resistant depression.Semantic proximity Read ↗

Lack of association of three GRIN2B polymorphisms with bipolar disorder.Semantic proximity Read ↗

GRIK4 polymorphism and its association with antidepressant response in depressed patients: a meta-analysis.Semantic proximity Read ↗

Influence of GNB3 C825T polymorphism on the efficacy of antidepressants in the treatment of major depressive disorder: A meta-analysis.Semantic proximity Read ↗

No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression.Semantic proximity Read ↗

Influence of GRIK4 genetic variants on the electroconvulsive therapy response.Semantic proximity Read ↗

Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder.Semantic proximity Read ↗

Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients.Semantic proximity Read ↗

Case-control association study of GRIA1, GRIA2 and GRIA4 polymorphisms in bipolar disorder.Semantic proximity Read ↗

Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.Semantic proximity Read ↗

No association of three GRIN2B polymorphisms with lithium response in bipolar patients.Semantic proximity Read ↗

Relationship between G-protein beta-3 subunit C825T polymorphism and mirtazapine responses in Korean patients with major depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.