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EctopicAtoh1expression drives Merkel cell production in embryonic, postnatal and adult epidermis

1 Jan 2015

Abstract excerpt

Merkel cells are mechanosensitive skin cells whose production requires the basic helix-loop-helix transcription factor Atoh1. We induced ectopic Atoh1 expression in the skin of transgenic mice to determine whether Atoh1 was sufficient to create additional Merkel cells. In embryos, ectopic Atoh1 expression drove ectopic expression of the Merkel cell marker keratin 8 (K8) throughout the epidermis. Epidermal Atoh1...

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PMID: 26138479
DOI: 10.1242/dev.123141

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