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Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR 2‐mediated signalling

13 Feb 2019

Abstract excerpt

Merkel cells are mechanosensory cells involved in tactile discrimination. Merkel cells have been primarily studied in the murine back skin, where they are found in specialized structures called touch domes located around primary hair follicles. Yet, little is known about the morphogenesis of Merkel cells in areas of the skin devoid of hair, such as the glabrous paw skin. Here, we describe Merkel cell formation in...

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PMID: 30758073
DOI: 10.1111/exd.13901

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Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR 2‐mediated signallingPMID 30758073Read ↗

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cellsSemantic proximity Read ↗

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The Touch Dome Defines an Epidermal Niche Specialized for Mechanosensory SignalingSemantic proximity Read ↗

The cellular basis of mechanosensory Merkel-cell innervation during developmentSemantic proximity Read ↗

Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasisSemantic proximity Read ↗

Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor networkSemantic proximity Read ↗

A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.Semantic proximity Read ↗

Identification of epidermal progenitors for the Merkel cell lineageSemantic proximity Read ↗

Characterisation of human hair follicle developmentSemantic proximity Read ↗

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