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Unipotent,<i>Atoh1</i>+ progenitors maintain the Merkel cell population in embryonic and adult mice

26 Jan 2015

Abstract excerpt

Resident progenitor cells in mammalian skin generate new cells as a part of tissue homeostasis. We sought to identify the progenitors of Merkel cells, a unique skin cell type that plays critical roles in mechanosensation. We found that some Atoh1-expressing cells in the hairy skin and whisker follicles are mitotically active at embryonic and postnatal ages. Genetic fate-mapping revealed that these...

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PMID: 25624394
DOI: 10.1083/jcb.201407101

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