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Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice

10 Feb 2022

Abstract excerpt

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and expresses viral transforming antigens (TAgs). MCC tumor cells also express signature genes detected in skin-resident, postmitotic Merkel cells, including atonal bHLH transcription factor 1 (ATOH1), which is required for Merkel cell development from epidermal...

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PMID: 35143422
DOI: 10.1172/jci152069

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