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Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis

28 Sept 2009

Abstract excerpt

Merkel cells (MCs) are located in the touch-sensitive area of the epidermis and mediate mechanotransduction in the skin. Whether MCs originate from embryonic epidermal or neural crest progenitors has been a matter of intense controversy since their discovery >130 yr ago. In addition, how MCs are maintained during adulthood is currently unknown. In this study, using lineage-tracing experiments, we show that MCs...

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PMID: 19786578
DOI: 10.1083/jcb.200907080

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