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The Touch Dome Defines an Epidermal Niche Specialized for Mechanosensory Signaling

30 May 2013

Abstract excerpt

In mammalian skin, Merkel cells are mechanoreceptor cells that are required for the perception of gentle touch. Recent evidence indicates that mature Merkel cells descend from the proliferative layer of skin epidermis; however, the stem cell niche for Merkel cell homeostasis has not been reported. Here, we provide genetic evidence for maintenance of mature Merkel cells during homeostasis by Krt17+ stem cells...

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Identifiers

PMID: 23727240
DOI: 10.1016/j.celrep.2013.04.026

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Related research

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Research trail→

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The Touch Dome Defines an Epidermal Niche Specialized for Mechanosensory SignalingPMID 23727240Read ↗

Identification of epidermal progenitors for the Merkel cell lineageSemantic proximity Read ↗

Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasisSemantic proximity Read ↗

Merkel cells and touch domes: more than mechanosensory functions?Semantic proximity Read ↗

The cellular basis of mechanosensory Merkel-cell innervation during developmentSemantic proximity Read ↗

Unipotent,<i>Atoh1</i>+ progenitors maintain the Merkel cell population in embryonic and adult miceSemantic proximity Read ↗

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cellsSemantic proximity Read ↗

Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR 2‐mediated signallingSemantic proximity Read ↗

A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.Semantic proximity Read ↗

Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor networkSemantic proximity Read ↗

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Dual innervation of neonatal Merkel cells in mouse touch domes.Semantic proximity Read ↗

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