Article
Somatic cell mutations caused by 365 nm LED-UVA due to DNA double-strand breaks through oxidative damage.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology - 1 Sept 2014
Fang Xing, Ide Naohiro, Higashi Sho-Ichi, Kamei Yasuhiro, Toyooka Tatsushi, Ibuki Yuko, Kawai Kazuaki, Kasai Hiroshi, Okamoto Keinosuke, Arimoto-Kobayashi Sakae, Negishi Tomoe
Abstract excerpt
Evidence is accumulating indicating that UVA (320-400 nm ultraviolet light) plays an important role in photo-carcinogenesis. UVA is thought to produce reactive oxygen species in irradiated cells through photo-activation of inherent photosensitizers, and was recently reported to cause DNA double-strand breaks (DSBs) in exposed cells. We have investigated the involvement of UVA in mutations and DNA damage in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.