Article
On the use of excision repair defective cells in the wing somatic mutation and recombination test in Drosophila melanogaster.
Environmental and molecular mutagenesis - 1 Jan 1990
Graf U, Hall C B, van Schaik N
Abstract excerpt
Ten chemical mutagens were tested in the wing somatic mutation and recombination test in Drosophila melanogaster. This assay makes use of genetic markers expressed on the wing of adult flies. Larvae which are trans-heterozygous for mwh (multiple wing hairs) and flr (flare) were fed with the compounds either acutely (2, 4, or 6 hr) or chronically (48 or 72 hr), or were treated by inhalation (1 hr). Genetic changes...
Topics
- Animals
- Crosses, Genetic
- DNA Repair
- Drosophila melanogaster
- Female
- Genetic Markers
- Male
- Mutagenicity Tests
- Mutagens
- Mutation
- Phenotype
- Recombination, Genetic