Article
CD200/BTLA deletions in pediatric precursor B-cell acute lymphoblastic leukemia treated according to the EORTC-CLG 58951 protocol.
Haematologica - 1 Oct 2015
Ghazavi Farzaneh, Clappier Emmanuelle, Lammens Tim, Suciu Stefan, Caye Aurélie, Zegrari Samira, Bakkus Marleen, Grardel Nathalie, Benoit Yves, Bertrand Yves, Minckes Odile, Costa Vitor, Ferster Alina, Mazingue Françoise, Plat Geneviève, Plouvier Emmanuel, Poirée Marilyne, Uyttebroeck Anne, van der Werff-Ten Bosch Jutte, Yakouben Karima, Helsmoortel Hetty, Meul Magali, Van Roy Nadine, Philippé Jan, Speleman Frank, Cavé Hélène, Van Vlierberghe Pieter, De Moerloose Barbara
Abstract excerpt
DNA copy number analysis has been instrumental for the identification of genetic alterations in B-cell precursor acute lymphoblastic leukemia. Notably, some of these genetic defects have been associated with poor treatment outcome and might be relevant for future risk stratification. In this study, we characterized recurrent deletions of CD200 and BTLA genes, mediated by recombination-activating genes, and used...
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