Article
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
International journal of hematology - 1 Sept 2018
Tomoyasu Chihiro, Imamura Toshihiko, Tomii Toshihiro, Yano Mio, Asai Daisuke, Goto Hiroaki, Shimada Akira, Sanada Masashi, Iwamoto Shotaro, Takita Junko, Minegishi Masayoshi, Inukai Takeshi, Sugita Kanji, Hosoi Hajime
Abstract excerpt
In this study, we performed genetic analysis of 83 B cell precursor acute lymphoblastic leukemia (B-ALL) cell lines. First, we performed multiplex ligation-dependent probe amplification analysis to identify copy number abnormalities (CNAs) in eight genes associated with B-ALL according to genetic subtype. In Ph+ B-ALL cell lines, the frequencies of IKZF1, CDKN2A/2B, BTG1, and PAX5 deletion were significantly...
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