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Article

Functional and Morphological Improvement of Dystrophic Muscle by Interleukin 6 Receptor Blockade.

EBioMedicine - 1 Apr 2015

Pelosi Laura, Berardinelli Maria Grazia, De Pasquale Loredana, Nicoletti Carmine, D'Amico Adele, Carvello Francesco, Moneta Gian Marco, Catizone Angela, Bertini Enrico, De Benedetti Fabrizio, Musarò Antonio

Abstract excerpt

The anti-inflammatory agents glucocorticoids (GC) are the only available treatment for Duchenne muscular dystrophy (DMD). However, long-term GC treatment causes muscle atrophy and wasting. Thus, targeting specific mediator of inflammatory response may be more specific, more efficacious, and with fewer side effects. The pro-inflammatory cytokine interleukin (IL) 6 is overproduced in patients with DMD and in the...

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Source

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Identifiers

PMID: 26137572
DOI: 10.1016/j.ebiom.2015.02.014
PMCID: PMC4485902

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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