Article

GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD

2025-10-15

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a fatal disease caused by dystrophin deficiency, leading to degeneration of the entire musculature. To improve muscle pathophysiology and gene therapy for DMD, we investigated the potential of growth differentiation factor 5 (GDF5) in the DMD mdx mouse model. We showed that the overexpression of GDF5 in the muscle improved its histology, reduced inflammation, modulated regenera...

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Literature Corpus work: 1bd6e369-0a3e-5ba0-9ed3-06f0959d468d
DOI: 10.1101/2025.10.14.682261

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