Article
Potent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin α2 chain-deficient muscular dystrophy.
Scientific reports - 10 Mar 2017
Gawlik Kinga I, Holmberg Johan, Svensson Martina, Einerborg Mikaela, Oliveira Bernardo M S, Deierborg Tomas, Durbeej Madeleine
Abstract excerpt
A large number of human diseases are caused by chronic tissue injury with fibrosis potentially leading to organ failure. There is a need for more effective anti-fibrotic therapies. Congenital muscular dystrophy type 1A (MDC1A) is a devastating form of muscular dystrophy caused by laminin α2 chain-deficiency. It is characterized with early inflammation and build-up of fibrotic lesions, both in patients and MDC1A...
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