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Article

An anti-inflammatory role for leukemia inhibitory factor receptor signaling in regenerating skeletal muscle.

Histochemistry and cell biology - 1 Jan 2013

Hunt Liam C, Upadhyay Aradhana, Jazayeri Jalal A, Tudor Elizabeth M, White Jason D

Abstract excerpt

Skeletal muscle regeneration in pathology and following injury requires the coordinated actions of inflammatory cells and myogenic cells to remove damaged tissue and rebuild syncytial muscle cells, respectively. Following contusion injury to muscle, the cytokine leukemia inhibitor factor (LIF) is up-regulated and knockout of Lif negatively impacts on morphometric parameters of muscle regeneration. Although it was...

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Identifiers

PMID: 22926285
DOI: 10.1007/s00418-012-1018-0

Genes

LIF

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