Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis.

doi:10.1093/jnci/djv178

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Article

Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis.

Journal of the National Cancer Institute - 1 Sept 2015

Nead Kevin T, Sharp Stephen J, Thompson Deborah J, Painter Jodie N, Savage David B, Semple Robert K, Barker Adam, Perry John R B, Attia John, Dunning Alison M, Easton Douglas F, Holliday Elizabeth, Lotta Luca A, O'Mara Tracy, McEvoy Mark, Pharoah Paul D P, Scott Rodney J, Spurdle Amanda B, Langenberg Claudia, Wareham Nicholas J, Scott Robert A

Abstract excerpt

BACKGROUND: Insulinemia and type 2 diabetes (T2D) have been associated with endometrial cancer risk in numerous observational studies. However, the causality of these associations is uncertain. Here we use a Mendelian randomization (MR) approach to assess whether insulinemia and T2D are causally associated with endometrial cancer. METHODS: We used single nucleotide polymorphisms (SNPs) associated with T2D (49...

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Identifiers

PMID: 26134033
DOI: 10.1093/jnci/djv178
PMCID: PMC4572886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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