Article
Causality between insulin use and malignant tumors of the digestive system: a two-sample mendelian randomized study.
BMC cancer - 7 Jan 2025
Chen DengZhuo, Ma YongLi, Li JingHui, Wen Liang, Zhang GuoSheng, Huang ChengZhi, Yao XueQing
Abstract excerpt
BACKGROUND: Existing cohort studies show no association between insulin use and cancers of the digestive system, while numerous meta-analyses suggest that insulin use increases the risk of digestive system tumours. This study uses two-sample Mendelian randomization (MR) to further investigate the causal relationship between the two. METHODS: We selected single nucleotide polymorphisms (SNPs) strongly associated...
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