Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis.

doi:10.1093/jnci/djac011

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Article

Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis.

Journal of the National Cancer Institute - 9 May 2022

Murphy Neil, Song Mingyang, Papadimitriou Nikos, Carreras-Torres Robert, Langenberg Claudia, Martin Richard M, Tsilidis Konstantinos K, Barroso Inês, Chen Ji, Frayling Timothy M, Bull Caroline J, Vincent Emma E, Cotterchio Michelle, Gruber Stephen B, Pai Rish K, Newcomb Polly A, Perez-Cornago Aurora, van Duijnhoven Franzel J B, Van Guelpen Bethany, Vodicka Pavel, Wolk Alicja, Wu Anna H, Peters Ulrike, Chan Andrew T, Gunter Marc J

Abstract excerpt

BACKGROUND: Glycemic traits-such as hyperinsulinemia, hyperglycemia, and type 2 diabetes-have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. We used Mendelian randomization (MR) to estimate the causal effects of fasting insulin, 2-hour glucose, fasting glucose, glycated hemoglobin (HbA1c), and type 2 diabetes with colorectal...

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Identifiers

PMID: 35048991
DOI: 10.1093/jnci/djac011
PMCID: PMC9086764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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