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Article

Validation of a 2-day water maze protocol in mice.

Behavioural brain research - 23 Jan 2009

Gulinello Maria, Gertner Michael, Mendoza Guadalupe, Schoenfeld Brian P, Oddo Salvatore, LaFerla Frank, Choi Catherine H, McBride Sean M J, Faber Donald S

Abstract excerpt

We present a 2-day water maze protocol that addresses some of potential confounds present in the water maze when using the aged subjects typical of studies of neurodegenerative disorders, such as Alzheimer's disease. This protocol is based on an initial series of training trials with a visible platform, followed by a memory test with a hidden platform 24h later. We validated this procedure using aged (15-18m)...

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Identifiers

PMID: 18831990
DOI: 10.1016/j.bbr.2008.09.002
PMCID: PMC4303046

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APP

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