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Effects of the genetic background on cognitive performances of TG2576 mice.

Behavioural brain research - 5 Aug 2008

Lassalle Jean Michel, Halley Hélène, Daumas Stéphanie, Verret Laure, Francés Bernard

Abstract excerpt

Animal models of genetic diseases obtained by transferring human mutated genes in the mouse are widely used in biomedical based research. They constitute efficient tools to study mechanisms underlying abnormal phenotypes. Unfortunately, the phenotype of the transgene is often obscured by the genetic background of the embryonic stem cells and that of the recipient strain used to create the transgenic line. It is...

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PMID: 18433892
DOI: 10.1016/j.bbr.2008.03.017

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