Article
Polymorphisms of MMP9 and TIMP2 in Patients with Varicose Veins.
In vivo (Athens, Greece) - 1 Jan 2000
Kunt Atike Tekeli, Isbir Selim, Gormus Uzay, Kahraman Ozlem Timirci, Arsan Sinan, Yilmaz Seda Gulec, Isbir Turgay
Abstract excerpt
BACKGROUND: Genetic predisposition is a suggested risk factor in the etiology of varicose veins. The matrix metalloproteinase (MMP) family degrades extracellular matrix (ECM) and may lead to disturbances in vein wall structure. The activity of MMPs in the ECM are controlled by specific tissue inhibitors of MMPs (TIMP). The present study aimed to investigate the relationship between MMP9 and TIMP2 gene...
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