Article
Polymorphism of Matrix Metalloproteinases Genes MMP1, MMP2, MMP3, and MMP7 and the Risk of Varicose Veins of Lower Extremities.
Bulletin of experimental biology and medicine - 1 Sept 2017
Shadrina A S, Smetanina M A, Sevost'yanova K S, Shevela A I, Seliverstov E I, Zakharova E A, Voronina E N, Ilyukhin E A, Zolotukhin I A, Kirienko A I, Filipenko M L
Abstract excerpt
We studied the effects of single nucleotide polymorphisms in the promoter regions of matrix metalloproteinase genes rs1799750 (-1607dupG) MMP1, rs243865 (C-1306T) MMP2, rs3025058 (-1171dupA) MMP3, and rs11568818 (A-181G) MMP7 on the risk of varicose vein of the lower extremities in ethnical Russians, residents of the Russian Federation. We genotyped 536 patients with this pathology and 273 healthy participants...
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