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Article

Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair.

Nucleic acids research - 3 Sept 2015

Ma Lijuan, Milman Neta, Nambiar Mridula, Smith Gerald R

Abstract excerpt

Meiotic programmed DNA double-strand break (DSB) repair is essential for crossing-over and viable gamete formation and requires removal of Spo11-oligonucleotide complexes from 5' ends (clipping) and their resection to generate invasive 3'-end single-stranded DNA (resection). Ctp1 (Com1, Sae2, CtIP homolog) acting with the Mre11-Rad50-Nbs1 (MRN) complex is required in both steps. We isolated multiple S. pombe ctp1...

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Identifiers

PMID: 26130711
DOI: 10.1093/nar/gkv644
PMCID: PMC4551917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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