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Article

Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions.

Molecular and cellular biology - 1 Apr 2009

Hartsuiker Edgar, Mizuno Kenichi, Molnar Monika, Kohli Juerg, Ohta Kunihiro, Carr Antony M

Abstract excerpt

The evolutionarily conserved Mre11/Rad50/Nbs1 (MRN) complex is involved in various aspects of meiosis. Whereas available evidence suggests that the Mre11 nuclease activity might be responsible for Spo11 removal in Saccharomyces cerevisiae, this has not been confirmed experimentally. This study demonstrates for the first time that Mre11 (Schizosaccharomyces pombe Rad32(Mre11)) nuclease activity is required for the...

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Identifiers

PMID: 19139281
DOI: 10.1128/MCB.01182-08
PMCID: PMC2655602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions.PMID 19139281Read ↗

The multiple roles of the Mre11 complex for meiotic recombination.Semantic proximity Read ↗

Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes.Semantic proximity Read ↗

Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe.Semantic proximity Read ↗

Association of Mre11p with double-strand break sites during yeast meiosis.Semantic proximity Read ↗

Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair.Semantic proximity Read ↗

Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.Semantic proximity Read ↗

Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30.Semantic proximity Read ↗

Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.Semantic proximity Read ↗

Physical interaction with Spo11 mediates the localisation of Mre11 to chromatin in meiosis and promotes its nuclease activity.Semantic proximity Read ↗

Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation.Semantic proximity Read ↗

Mechanism and control of meiotic recombination initiation.Semantic proximity Read ↗

Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable.Semantic proximity Read ↗

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