Enrichment of loss-of-function and copy number variants in ventricular cardiomyopathy genes in 'lone' atrial fibrillation.

doi:10.1093/europace/euaa421

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Enrichment of loss-of-function and copy number variants in ventricular cardiomyopathy genes in 'lone' atrial fibrillation.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 7 Jun 2021

Lazarte Julieta, Laksman Zachary W, Wang Jian, Robinson John F, Dron Jacqueline S, Leach Emma, Liew Janet, McIntyre Adam D, Skanes Allan C, Gula Lorne J, Leong-Sit Peter, Cao Henian, Trost Brett, Scherer Stephen W, Hegele Robert A, Roberts Jason D

Abstract excerpt

AIMS: Atrial fibrillation (AF) is a complex heritable disease whose genetic underpinnings remain largely unexplained, though recent work has suggested that the arrhythmia may develop secondary to an underlying atrial cardiomyopathy. We sought to evaluate for enrichment of loss-of-function (LOF) and copy number variants (CNVs) in genes implicated in ventricular cardiomyopathy in 'lone' AF. METHODS AND RESULTS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrial Fibrillation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiac electrophysiology and arrhythmias

Share to Cardiomyopathies

Share to DNA Copy Number Variations

Share to Genetic Predisposition to Disease

Share to Genomics and Rare Diseases

Share to Heterozygote

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 33682005
DOI: 10.1093/europace/euaa421
PMCID: PMC8184224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enrichment of loss-of-function and copy number variants in ventricular cardiomyopathy genes in 'lone' atrial fibrillation.PMID 33682005Read ↗

Loss-of-Function <i>FLNC</i> Variants are Associated with Arrhythmogenic Cardiomyopathy Phenotypes when Identified through Exome Sequencing of a General Clinical PopulationSemantic proximity Read ↗

Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation.Semantic proximity Read ↗

Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.Semantic proximity Read ↗

Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.Semantic proximity Read ↗

Loss-of-Function FLNC Variants Are Associated With Arrhythmogenic Cardiomyopathy Phenotypes When Identified Through Exome Sequencing of a General Clinical Population.Semantic proximity Read ↗

Broad Genetic Testing in a Clinical Setting Uncovers a High Prevalence of Titin Loss-of-Function Variants in Very Early Onset Atrial FibrillationSemantic proximity Read ↗

Candidate gene approach to identifying rare genetic variants associated with lone atrial fibrillation.Semantic proximity Read ↗

A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillationSemantic proximity Read ↗

Common variants in KCNN3 are associated with lone atrial fibrillation.Semantic proximity Read ↗

Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results From a National Biobank.Semantic proximity Read ↗

Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation.Semantic proximity Read ↗

Genetics of atrial fibrillation: from families to genomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.