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Article

Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Oct 2015

Ayo Christiane Maria, Oliveira Amanda Priscila de, Camargo Ana Vitória da Silveira, Mattos Cinara Cássia Brandão de, Bestetti Reinaldo Bulgarelli, Mattos Luiz Carlos de

Abstract excerpt

MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD.

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Share to Chagas Cardiomyopathy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NK Cell Lectin-Like Receptor Subfamily K

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Source

Open in PubMed Open full text

Identifiers

PMID: 26129751
DOI: 10.1093/cid/civ540
PMCID: PMC4583584

Genes

MICA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.PMID 26129751Read ↗

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