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Article

Routine Clinical Mutation Profiling of Non-Small Cell Lung Cancer Using Next-Generation Sequencing.

Archives of pathology & laboratory medicine - 1 Jul 2015

Deeb Kristin K, Hohman Colleen M, Risch Nicholas F, Metzger Daniel J, Starostik Petr

Abstract excerpt

CONTEXT: The availability of massive, parallel-sequencing technologies makes possible efficient, simultaneous detection of driver and druggable mutations in cancer. OBJECTIVE: To develop an amplicon-based, next-generation sequencing, mutation-detection assay for lung cancer using the 454 GS Junior (Roche Applied Science, Indianapolis, Indiana) platform. DESIGN: Fusion primers incorporating target sequence, 454...

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Source

Identifiers

PMID: 26125431
DOI: 10.5858/arpa.2014-0095-OA

Genes

KRAS
EGFR
ERBB2
PTEN
AKT1
BRAF
HRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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