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Validating a targeted next-generation sequencing assay and profiling somatic variants in Chinese non-small cell lung cancer patients.

Scientific reports - 7 Feb 2020

Jiang Ruirui, Zhang Bo, Teng Xiaodong, Hu Peizhen, Xu Sanpeng, Zheng Zuyu, Liu Rui, Tang Tingdong, Ye Feng

Abstract excerpt

Non-small cell lung cancer (NSCLC) is featured with complex genomic alterations. Molecular profiling of large cohort of NSCLC patients is thus a prerequisite for precision medicine. We first validated the detection performance of a next-generation sequencing (NGS) cancer hotspot panel, OncoAim, on formalin-fixed paraffin-embedded (FFPE) samples. We then utilized OncoAim to delineate the genomic aberrations in...

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Identifiers

PMID: 32034196
DOI: 10.1038/s41598-020-58819-5
PMCID: PMC7005734

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