Article
Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2015
Sholl Lynette M, Aisner Dara L, Varella-Garcia Marileila, Berry Lynne D, Dias-Santagata Dora, Wistuba Ignacio I, Chen Heidi, Fujimoto Junya, Kugler Kelly, Franklin Wilbur A, Iafrate A John, Ladanyi Marc, Kris Mark G, Johnson Bruce E, Bunn Paul A, Minna John D, Kwiatkowski David J
Abstract excerpt
INTRODUCTION: Molecular genetic analyses of lung adenocarcinoma have recently become standard of care for treatment selection. The Lung Cancer Mutation Consortium was formed to enable collaborative multi-institutional analyses of 10 potential oncogenic driver mutations. Technical aspects of testing and clinicopathologic correlations are presented. METHODS: Mutation testing in at least one of the eight genes...
Topics
- Adenocarcinoma
- Adrenal Gland Neoplasms
- Anaplastic Lymphoma Kinase
- Bone Neoplasms
- Class I Phosphatidylinositol 3-Kinases
- Cooperative Behavior
- DNA Mutational Analysis
- Female