Validity of Targeted Next-Generation Sequencing in Routine Care for Identifying Clinically Relevant Molecular Profiles in Non-Small-Cell Lung Cancer: Results of a 2-Year Experience on 1343 Samples.

doi:10.1016/j.jmoldx.2018.04.002

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Article

Validity of Targeted Next-Generation Sequencing in Routine Care for Identifying Clinically Relevant Molecular Profiles in Non-Small-Cell Lung Cancer: Results of a 2-Year Experience on 1343 Samples.

The Journal of molecular diagnostics : JMD - 1 Jul 2018

Legras Antoine, Barritault Marc, Tallet Anne, Fabre Elizabeth, Guyard Alice, Rance Bastien, Digan William, Pecuchet Nicolas, Giroux-Leprieur Etienne, Julie Catherine, Jouveshomme Stéphane, Duchatelle Véronique, Giraudet Véronique, Gibault Laure, Cazier Alain, Pastre Jean, Le Pimpec-Barthes Françoise, Laurent-Puig Pierre, Blons Hélène

Abstract excerpt

Theranostic assays are based on single-gene testing, but the ability of next-generation sequencing (NGS) to interrogate numerous genetic alterations will progressively replace single-gene assays. Although NGS was evaluated to screen for theranostic mutations, its usefulness in clinical practice on large series of samples remains to be demonstrated. NGS performance was assessed following guidelines. TaqMan probes...

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PMID: 29787863
DOI: 10.1016/j.jmoldx.2018.04.002

Genes

EGFR
KRAS
CTNNB1
STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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