Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Psychometric precision in phenotype definition is a useful step in molecular genetic investigation of psychiatric disorders.

Translational psychiatry - 30 Jun 2015

Xu M K, Gaysina D, Barnett J H, Scoriels L, van de Lagemaat L N, Wong A, Richards M, Croudace T J, Jones P B

Abstract excerpt

Affective disorders are highly heritable, but few genetic risk variants have been consistently replicated in molecular genetic association studies. The common method of defining psychiatric phenotypes in molecular genetic research is either a summation of symptom scores or binary threshold score representing the risk of diagnosis. Psychometric latent variable methods can improve the precision of psychiatric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Association Studies
Share to Mental Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Biology

Share to Mood Disorders

Share to Polymorphism, Single Nucleotide

Share to Psychiatric Status Rating Scales

Share to Psychometrics

Share to Surveys and Questionnaires

Source

Open in PubMed Open full text

Identifiers

PMID: 26125156
DOI: 10.1038/tp.2015.86
PMCID: PMC4490295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Psychometric precision in phenotype definition is a useful step in molecular genetic investigation of psychiatric disorders.PMID 26125156Read ↗

Polygenic risk scores in psychiatry: Will they be useful for clinicians?Semantic proximity Read ↗

Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.Semantic proximity Read ↗

Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.Semantic proximity Read ↗

A Systematic Review and Analysis of the Use of Polygenic Scores in Pharmacogenomics.Semantic proximity Read ↗

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits.Semantic proximity Read ↗

Phenotypically independent profiles relevant to mental health are genetically correlated.Semantic proximity Read ↗

Phenotypically independent profiles relevant to mental health are genetically correlatedSemantic proximity Read ↗

The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: A systematic review.Semantic proximity Read ↗

Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?Semantic proximity Read ↗

Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study.Semantic proximity Read ↗

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression in the VA Health Care SystemSemantic proximity Read ↗

Prospects for using risk scores in polygenic medicine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.