Article
Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.
Molecular psychiatry - 1 Dec 2023
Waszczuk Monika A, Jonas Katherine G, Bornovalova Marina, Breen Gerome, Bulik Cynthia M, Docherty Anna R, Eley Thalia C, Hettema John M, Kotov Roman, Krueger Robert F, Lencz Todd, Li James J, Vassos Evangelos, Waldman Irwin D
Abstract excerpt
Genome-wide association studies (GWAS) provide biological insights into disease onset and progression and have potential to produce clinically useful biomarkers. A growing body of GWAS focuses on quantitative and transdiagnostic phenotypic targets, such as symptom severity or biological markers, to enhance gene discovery and the translational utility of genetic findings. The current review discusses such...
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