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Article

Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine.

Neoplasia (New York, N.Y.) - 1 Jan 2021

Rivera Maria, Fichtner Iduna, Wulf-Goldenberg Annika, Sers Christine, Merk Johannes, Patone Giannino, Alp Keziban M, Kanashova Tamara, Mertins Philipp, Hoffmann Jens, Stein Ulrike, Walther Wolfgang

Abstract excerpt

Patient-derived xenograft (PDX) tumor models represent a valuable platform for identifying new biomarkers and novel targets, to evaluate therapy response and resistance mechanisms. This study aimed at establishment, characterization and therapy testing of colorectal carcinoma-derived PDX. We generated 49 PDX and validated identity between patient tumor and corresponding PDX. Sensitivity of PDX toward conventional...

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Identifiers

PMID: 33212364
DOI: 10.1016/j.neo.2020.11.005
PMCID: PMC7680704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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