Article
Distribution and Effects of CDKN2 p16 540 C>G and 580 C>T, and MDM2 SNP309 T>G Polymorphisms in Patients with Primary Brain Tumors.
Anticancer research - 1 Jul 2015
Kafadar Ali, Küçükhüseyin Özlem, Turan Saime, Yenilmez Ezgi Nurdan, Tunoglu Servet, Zeybek Umit, Kaynar Mehmet Yasar, Kemerdere Rahsan, Yaylim Ilhan
Abstract excerpt
BACKGROUND/AIM: Primary brain tumors are unique tumors due to their different pathobiological behavior, while they rarely metastasize outside the central nervous system. Regarding the oncogenesis of primary brain tumors, it was shown that changes in functions of p16 and mouse double minute 2 homolog (MDM2) are related to tumor pathogenesis by enhancing cell proliferation and malign development. The present study...
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