Article
Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia.
Human molecular genetics - 15 Aug 2003
Wong Jasmine C Y, Alon Noa, Mckerlie Colin, Huang Jun R, Meyn M Stephen, Buchwald Manuel
Abstract excerpt
Fanconi Anemia (FA) is an autosomal recessive disorder characterized by cellular hypersensitivity to DNA cross-linking agents. Recent studies suggest that FA proteins share a common pathway with BRCA proteins. To study the in vivo role of the FA group A gene (Fanca), gene-targeting techniques wer...
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