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Structural insights into the polytopic Escherichia coli phosphoglycosyl transferase WbaP.

Open biology - 19 Aug 2026

Weckener Miriam, Le Bas Audrey, Ward Philip N, Clarke Bradley R, Harrison Peter J, McMahon Stephen A, Liu Huanting, Eddershaw Alice, Giltrap Andrew M, Pardon Els, Lakshminarayanan Abirami, Steyaert Jan, Davis Benjamin G, Whitfield Chris, Naismith James H

Abstract excerpt

Host-pathogen interactions frequently depend on key components of the bacterial cell surface, such as capsules and lipopolysaccharides in Gram-negative bacteria. The first step in the synthesis of lipid-linked polysaccharides is the substitution of a uridine diphosphate (UDP)-sugar by a lipid monophosphate catalysed by a phosphoglycosyl transferase (PGT). We report the 3.0 Å cryo-electron microscopy apo-structure...

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PMID: 42613053
DOI: 10.1098/rsob.250369

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